Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review

A. Ehrmann, Polymers 13 (2021).

Artikel | Veröffentlicht | Englisch
Autor*in
Abstract
Electrospinning can be used to prepare nanofiber mats from diverse polymers, polymer blends, or polymers doped with other materials. Amongst this broad range of usable materials, biopolymers play an important role in biotechnological, biomedical, and other applications. However, several of them are water-soluble, necessitating a crosslinking step after electrospinning. While crosslinking with glutaraldehyde or other toxic chemicals is regularly reported in the literature, here, we concentrate on methods applying non-toxic or low-toxic chemicals, and enzymatic as well as physical methods. Making gelatin nanofibers non-water soluble by electrospinning them from a blend with non-water soluble polymers is another method described here. These possibilities are described together with the resulting physical properties, such as swelling behavior, mechanical strength, nanofiber morphology, or cell growth and proliferation on the crosslinked nanofiber mats. For most of these non-toxic crosslinking methods, the degree of crosslinking was found to be lower than for crosslinking with glutaraldehyde and other common toxic chemicals.
Erscheinungsjahr
Zeitschriftentitel
Polymers
Band
13
Zeitschriftennummer
12
Artikelnummer
1973
eISSN
FH-PUB-ID

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Ehrmann, Andrea: Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review. In: Polymers Bd. 13, MDPI AG (2021), Nr. 12
Ehrmann A. Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review. Polymers. 2021;13(12). doi:10.3390/polym13121973
Ehrmann, A. (2021). Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review. Polymers, 13(12). https://doi.org/10.3390/polym13121973
@article{Ehrmann_2021, title={Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review}, volume={13}, DOI={10.3390/polym13121973}, number={121973}, journal={Polymers}, publisher={MDPI AG}, author={Ehrmann, Andrea}, year={2021} }
Ehrmann, Andrea. “Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review.” Polymers 13, no. 12 (2021). https://doi.org/10.3390/polym13121973.
A. Ehrmann, “Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review,” Polymers, vol. 13, no. 12, 2021.
Ehrmann, Andrea. “Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine—A Review.” Polymers, vol. 13, no. 12, 1973, MDPI AG, 2021, doi:10.3390/polym13121973.
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